Long-term storage of vitrified oocytes does not affect pregnancy and live birth rates: analysis of 41,783 oocytes from 5,362 cycles
Vitrification is the most efficient approach for oocyte cryopreservation. It is commonly applied in oocyte donation programs and considered safe. However, the effect of long-term storage of oocytes on laboratory and reproductive outcomes has not been properly investigated.
To address this, Torra-Massana and co-authors have analysed a cohort of 5,362 cycles corresponding to more than 41.000 vitrified oocytes. The storage time of these oocytes ranged from 0 to 8 years, and they were all stored in nitrogen vapor tanks.
The research found that: 1) The average oocyte survival and fertilization rates were close to 90% and 70%, respectively, in all time categories, and did not decrease with longer storage time. 2) The average oocyte storage time was comparable between those cycles with positive and negative pregnancy. The adjusted analysis further supported that storage time does not have a significant effect on biochemical and pregnancy rates, nor on live birth rate after the fresh ET.
https://www.sciencedirect.com/science/article/abs/pii/S1472648323002742
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